The result of a mathematical development should be continuously checked against one's own intuition about what constitutes reasonable biological behavior. When such a check reveals disagreement, the the following possibilities must be considered:
a. A mistake has been made in the formal mathematical development;
b. The starting assumptions are incorrect and/or constitute a too drastic oversimplification;
c. One's own intuition about the biological field is inadequately developed;
d. A penetrating new principle has been discovered.
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